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Michael Long, Ph.D., President & CEO
The Unmet Need. Animal lameness caused by osteo-inflammatory disease is a serious health problem that has multiple etiologies. In horses, orthopedic injuries limit performance and can result in fatal bone failures; in dogs and cats inflammation-related events and age-related arthritis limit the quality of life. There are no FDA approved therapies that cure or prevent animal lameness or OA. The existing therapies for lameness in companion animals are palliative and are aimed at controlling the associated inflammation.
Lameness typically develops as a repetitive stress injury (see Figure), e.g., foreleg impact in race-horses, joint pressure in overweight dogs and cats. The resulting inflammation produces proteins that abet that process, but also cause increased bone loss. This weakens the limb leading to further/greater injury and thus establishes a vicious cycle. FreeStride’s drug arrests this cycle at two points.
The Solution. FreeStride’s drug uniquely prevents both inflammation, and bone loss/alterations that occur in inflammatory skeletal disease. It is a small molecule, orally available, has a well-defined molecular target and a tri-modal MOA: the drug halts enzymatic degradation of bone, it promotes bone formation (long term), and it powerfully blocks the release of inflammatory proteins by immune cells. The use of the FreeStride drug therefore represents a novel therapy that affects both immunity and bone homeostasis.
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